The Ulijasz lab (www.ulijaszlab.com) at Loyola University Chicago Department of Microbiology and Immunology is recruiting a highly motivated postdoctoral researcher to work on a recently NIH funded project in the area of molecular microbiology. Our lab researches molecular mechanisms of bacterial signal transduction/sensors in both Gram-negative and Gram-positive bacterial pathogens. To accomplish this, we and our collaborators use a holistic and innovative array of methods, including high-throughput sequencing, protein biochemistry/molecular biology, structural biology, super resolution microscopy and animal infections to reveal novel proteins and pathways that contribute to microbial disease.
Using a novel screening method, metabolic-coupled tn-sequencing (Met-seq; Glanville et al. mSystems, 2021), the Ulijasz lab has recently discovered a subset of protein domains that bind heme and sense and responds to glyoxal; a ubiquitous toxin that results from glycolysis. The accumulation of glyoxal (and methylglyoxal) is thought to be an underlying cause of many human diseases though its irreversible damage to key proteins. In prokaryotes the mechanisms of glyoxal sensing and response are especially enigmatic. The project will entail investigating how this novel family of proteins sensing and responds to glyoxal in the pathogen Pseudomonas aeruginosa, and possibly other microorganisms, using a series of molecular techniques.
Candidates should have a Ph.D. in Microbiology, Molecular Biology, Biochemistry or related field. The successful candidate will have a strong background in microbial genetics and molecular biology, including protein expression and purification, and the ability to conduct his/her research independently. The candidate will be working with several collaborating labs on aspects of the project. Applicants with a knowledge base in protein-protein interactions, and/or mass spectrometry and/or super resolution microscopy would be preferred, but is not required.
The Ulijasz lab is located at Loyola University Chicago in the western Chicago suburbs. Located in the midwestern United States in the state of Illinois. Chicago is the 3th largest city in the US, and home to several national sports teams, a top-rated and ethnically diverse restaurant scene and world renowned entertainment. Housing is affordable and the city/surrounding areas offer accessible and safe public transit around the city.
The postdoctoral salary meets the NIH NRSA standards and is based on qualifications and experience: https://grants.nih.gov/grants/guide/notice-files/NOT-OD-21-049.html. Interested candidates should send an application packet, including all the following by email to email@example.com
Cover letter indicating current and future research interests;
2. Expected starting date
- Curriculum vitae;
4. Names and contact information for 3 references
Read the full article at: https://jobs.chronicle.com/job/445346/research-associate-ulijasz-lab-/