The laboratory of Dr. Joel Belasco at New York University School of Medicine (www.belascolab.org) is
seeking a highly motivated individual for postdoctoral research on post-transcriptional gene regulation at
the intersection of RNA biology, biochemistry, and microbiology. The goal of this research will be to
elucidate the molecular mechanisms that govern mRNA lifetimes in bacterial cells. This is a full-time
position supported by a five-year NIH grant.
These studies are prompted by our recent discovery of two novel regulatory phenomena: (i) the presence
of noncanonical nucleoside tetraphosphate (Np4) caps on bacterial transcripts during disulfide stress (1-3)
and (ii) the linear scanning mechanism by which the endonuclease RNase E locates cleavage sites in
mRNAs as a prelude to initiating their degradation (4, 5). Each of these unexpected findings has important
consequences for the control of gene expression and has been implicated in bacterial pathogenesis and
stress responses. Our goal is to achieve a deep mechanistic understanding of these key cellular processes
and their impact on gene regulation by a multidisciplinary approach comprising a combination of in vivo
and in vitro strategies that encompass a variety of genetic, biochemical, and biophysical methods.
The Belasco laboratory is located in New York City. We value diligence, ingenuity, initiative, collegiality,
integrity, and diversity. Applicants must possess a Ph.D. degree or equivalent or be nearing the date of
their thesis defense. Strong analytical and oral communication skills and an ability to work both
independently and as a cooperative member of a team are required. Accomplished candidates with
expertise in various aspects of molecular biology will be considered; those with a background in RNA
biology or biochemistry are especially encouraged to apply. A competitive salary and excellent benefits
package are available. Previous postdocs in the Belasco lab have successfully continued on to independent
careers in academia and industry.
Please send your CV, a list of publications, the names and e-mail addresses of three references, and a
cover letter describing your background and professional goals to Dr. Joel G. Belasco
(email@example.com), using “Postdoctoral research” on the e-mail subject line.
Recent publications pertinent to these research projects:
1. Luciano DJ, Levenson-Palmer R, & Belasco JG (2019). Mol. Cell 75: 957–966.
2. Luciano DJ & Belasco JG (2020). Proc. Natl. Acad. Sci. USA 117: 3560-3567.
3. Levenson-Palmer R, Luciano DJ, Vasilyev N, Nuthanakanti A, Serganov A, & Belasco JG (2022).
Proc. Natl. Acad. Sci. USA 119: e2117318119.
4. Richards J & Belasco JG (2019). Mol. Cell 74: 284-295. 5. Richards J & Belasco JG (2021). Mol. Cell 81: 127-138.