Binding of HasA by its transmembrane receptor HasR follows a conformational funnel mechanism.Exner et al., 2019 Authors: Thomas E. Exner, Stefanie Becker, Simon Becker, Audrey Boniface-Guiraud, Philippe Delepelaire, Kay Diederichs, Wolfram Welte Abstract HasR in the outer membrane of Serratia marcescens binds secreted, heme-loaded HasA and translocates the heme to the periplasm to satisfy the cell’s demand for iron. The previously published crystal structure of the wild-type complex showed […]
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